Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol. 2013;9(2):106–118. doi: 10.1038/nrneurol.2012.263. Epub 2013 Jan 8. Erratum in: Nat Rev Neurol. 2013. doi: 10.1038/nmeurol.2013.32. Liu, Chia-Chan [corrected to Liu, Chia-Chen].
Lourida I, Hannon E, Littlejohns TJ, et al. Association of lifestyle and genetic risk with incidence of dementia. J Am Med Assoc. 2019;322(5):430–437. doi: 10.1001 /jama.2019.9879
Macey PM, Prasad JP, Ogren JA, et al. Sex-specific hippocampus volume changes in obstructive sleep apnea. Neuroimage Clin. 2018;20:305–317. doi: 10.1016 / j.nicl.2018.07.027
Mata IF, Leverenz JB, Weintraub D, et al. APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease. JAMA Neurol. 2014;71(11):1405–1412. doi: 10.1001/jamaneurol.2014.1455
Miller BL. Science denial and COVID conspiracy theories: potential neurological mechanisms and possible responses. J Am Med Assoc. 2020;324(22):2255–2256. doi: 10.1001/jama.2020.21332
Miller T, Cudkowicz M, Shaw PJ, et al. Phase 1–2 trial of antisense oligonucleotide tofersen for SOD1 ALS. N Engl J Med. 2020;383(2):109–119. doi: 10.1056/NEJM oa2003715
Molloy AM, Pangilinan F, Mills JL, et al. A common polymorphism in HIBCH influences methylmalonic acid concentrations in blood independently of cobalamin. Am J Hum Genet. 2016;98(5):869–882. doi: 10.1016/j.ajhg.2016.03.005. Epub 2016 Apr 28. 226 For Further Reading
Montagne A, Nation DA, Sagare AP, et al. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020;581(7806):71–76. doi: 10.1038/s41586-020-2247-3. Epub 2020 Apr 29.
Mormino EC, Betensky RA, Hedden T, et al. Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology. 2014;82(20):1760–1767. doi: 10.1212/WNL.0000000000000431. Epub 2014 Apr 18.
Nordström A, Nordström P. Traumatic brain injury and the risk of dementia diagnosis: a nationwide cohort study. PLoS Med. 2018;15(1):e1002496. doi: 10.1371/journal.pmed.1002496
O’Hara R, Luzon A, Hubbard J, Zeitzer JM. Sleep apnea, apolipoprotein epsilon 4 allele, and TBI: mechanism for cognitive dysfunction and development of dementia. J Rehabil Res Dev. 2009;46(6):837–850. doi: 10.1682/jrrd.2008.10.0140
Oveisgharan S, Wilson RS, Yu L, Schneider JA, Bennett DA. Association of earlylife cognitive enrichment with Alzheimer disease pathological changes and cognitive decline. JAMA Neurol. 2020;77(10):1217–1224. doi: 10.1001 /jamaneurol.2020.1941
Poewe W, Seppi K, Tanner CM, et al. Parkinson disease. Nat Rev Dis Primers. 2017;3:17013. doi: 10.1038/nrdp.2017.13
Proskovec AL, Rezich MT, O’Neill J, et al. Association of epigenetic metrics of biological age with cortical thickness. JAMA Netw Open. 2020;3(9):e2015428. doi: 10.1001/jamanetworkopen.2020.15428
Rainville JR, Hodes GE. Inflaming sex differences in mood disorders. Neuropsychopharmacology. 2019;44(1):184–199. doi: 10.1038/s41386-018-0124-7. Epub 2018 Jun 19.
Raz L, Knoefel J, Bhaskar K. The neuropathology and cerebrovascular mechanisms of dementia. J Cereb Blood Flow Metab. 2016;36(1):172–186. doi: 10.1038/jcbfm.2015.164
Reckelhoff JF. Gender differences in the regulation of blood pressure. Hypertension. 2001;37(5):1199–1208. doi: 10.1161/01.hyp.37.5.1199
Reiman EM, Chen K, Alexander GE, et al. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia. Proc Natl Acad Sci USA. 2004;101(1):284–289. doi: 10.1073/pnas.2635903100. Epub 2003 Dec 19.
Rosenberg RN, Lambracht-Washington D, Yu G, Xia W. Genomics of Alzheimer disease: a review. JAMA Neurol. 2016;73(7):867–874. doi: 10.1001/ jamaneurol.2016.0301
Rossor MN, Fox NC, Mummery CJ, Schott JM, Warren JD. The diagnosis of young-onset dementia. Lancet Neurol. 2010;9(8):793–806. doi: 10.1016/S1474-4422(10)70159–9
Salihu HM, King L, Patel P, et al. Association between maternal symptoms of sleep disordered breathing and fetal telomere length. Sleep. 2015;38(4):559–566. doi: 10.5665/sleep.4570
Salthouse T. Consequences of age-related cognitive declines. Annu Rev Psychol. 2012;63:201–226. doi: 10.1146/annurev-psych-120710-100328. Epub 2011 Jul 5.
Schumacher J, Peraza LR, Firbank M, et al. Dysfunctional brain dynamics and their origin in Lewy body dementia. Brain. 2019;142(6):1767–1782. doi: 10.1093/brain/awz069
Shively S, Scher AI, Perl DP, Diaz-Arrastia R. Dementia resulting from traumatic brain injury: what is the pathology? Arch Neurol. 2012;69(10):1245–1251. doi: 10.1001/archneurol.2011.3747
Sperling RA, Donohue MC, Raman R, et al. Association of factors with elevated amyloid burden in clinically normal older individuals. JAMA Neurol. 2020;77(6):735–745. doi: 10.1001/jamaneurol.2020.0387
Spira AP, Blackwell T, Stone KL, et al. Sleep-disordered breathing and cognition in older women. J Am Geriatr Soc. 2008;56(1):45–50. doi: 10.1111/j.1532–5415.2007.01506.x. Epub 2007 Nov 28.
Sulzer D, Antonini A, Leta V, et al. COVID-19 and possible links with Parkinson’s disease and Parkinsonism: from bench to bedside. NPJ Parkinsons Dis. 2020;6:18. doi: 10.1038/s41531-020-00123-0
Sun Y, Fang J, Wan Y, Su P, Tao F. Association of early-life adversity with measures of accelerated biological aging among children in China. JAMA Netw Open. 2020;3(9):e2013588. doi: 10.1001/jamanetworkopen.2020.13588
Tanda R, Salsberry PJ, Reagan PB, Fang MZ. The impact of prepregnancy obesity on children’s cognitive test scores. Matern Child Health J. 2013;17(2):222–229. doi: 10.1007/s10995-012-0964-4
Tshala-Katumbay D, Mwanza JC, Rohlman DS, Maestre G, Oriá RB. A global perspective on the influence of environmental exposures on the nervous system. Nature. 2015;527(7578):S187–S192. doi: 10.1038/nature16034228
Vo HT, Laszczyk AM, King GD. Klotho, the key to healthy brain aging? Brain Plast. 2018;3(2):183–194. doi: 10.3233/BPL-170057
Xu Y, Sun Z. Molecular basis of Klotho: from gene to function in aging. Endocr Rev. 2015 Apr;36(2):174–193. doi: 10.1210/er.2013–1079. Epub 2015 Feb 19.
Zhang H, Li Y, Fan Y, et al. Klotho is a target gene of PPAR-gamma. Kidney Int. 2008;74(6):732–739. doi: 10.1038/ki.2008.244. Epub 2008 Jun 11.
Zheng H, Koo EH. The amyloid precursor protein: beyond amyloid. Mol Neurodegener. 2006;1:5. doi: 10.1186/1750-1326-1-5
Zhou Q, Lin S, Tang R, et al. Role of Fosinopril and Valsartan on Klotho gene expression induced by Angiotensin II in rat renal tubular epithelial cells. Kidney Blood Press Res. 2010;33(3):186–192. doi: 10.1159/000316703
Chapter 4. Midlife Medical Conditions
That Affect Dementia Risk
Amarenco P, Kim JS, Labreuche J, et al. A comparison of two LDL cholesterol targets after ischemic stroke. N Engl J Med. 2020;382(1):9. doi: 10.1056/NEJM oa1910355. Epub 2019 Nov 18.
Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer’s disease. Acta Neuropathol. 2009;118(1):103–113. doi: 10.1007/s00401-009-0522-3. Epub 2009 Mar 25.
Biessels GJ, Whitmer RA. Cognitive dysfunction in diabetes: how to implement emerging guidelines. Diabetologia. 2020;63(1):3–9. doi: 10.1007/s00125-019-04977-9. Epub 2019 Aug 16.
Boehme C, Toell T, Mayer L, et al. The dimension of preventable stroke in a large representative patient cohort. Neurology. 2019;93(23):e2121–e2132. doi: 10.1212/WNL.0000000000008573. Epub 2019 Oct 31.
Bonda DJ, Lee HG, Camins A, et al. The critical role of the sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurol. 2011;10(3):275–279. doi: 10.1016/s1474-4422(11)70013-8
Borland E, Stomrud E, van Westen D, Hansson O, Palmqvist S. The age-related effect on cognitive performance in cognitively healthy elderly is mainly caused by underlying AD pathology or cerebrovascular lesions: implications for cutoffs regarding cognitive impairment. Alzheimers Res Ther. 2020;12(1):30. doi: 10.1186/s13195-020-00592-8
